CENTRO DE ESTUDIOS TRASLACIONALES EN ESTRÉS Y SALUD MENTAL

Pablo R. Moya Director de C-ESTRES

FORMACIÓN

  • 2011-2013 Research Fellow, National Institute of Mental Health, NIH, Bethesda, MD, EEUU

  • 2006-2011 Postdoctorado, Laboratory of Clinical Science, NIMH/NIH, Bethesda, MD, EEUU
  • 2005 Doctor en Ciencias Biomédicas (Universidad de Chile)            
  • 1999 Bioquímico (Universidad de Santiago de Chile)

PROYECTOS

2024-presente    Director. Proyecto CIDI 003. Centro de Estudios Traslacionales en Estrés y Salud Mental C-ESTRES. , Universidad de Valparaíso

2024-2027     Director Alterno. Exploración 13240064. DeepSurf: Control de red para una alternativa de superficie a la estimulación cerebral profunda y su validación en un modelo de ratón de trastorno obsesivo-compulsivo. ANID Chile.

2023-2025     Director Alterno. FONIS SA23I0179. Evaluación de la efectividad de una intervención psicoeducativa para el manejo del estrés sobre los niveles de cortisol, ansiedad y rendimiento académico en alumnos de la Academia Politécnica Naval. ANID Chile.

2023-2027     Investigador Responsable. FONDECYT Regular 1231012. The role of the excitatory amino acid transporter EAAT3 in depressive behavior induced by chronic stress. ANID Chile

2022-2025     Investigador Asociado. ANILLO Nº ATE220020. One Health Network: Dengue and Emerging Medically Important Arboviruses (DEMIV‐OH). ANID Chile

2022-2026     Co-Investigador. FONDECYT Regular 1221003. Endocannabinoid modulation of specific inhibitory circuits that regulate cortical function. ANID Chile

2019-2023     Investigador Responsable. FONDECYT Regular 1190833. Molecular and Functional Evaluation of a Mouse Model of Obsessive-Compulsive Disorder with Increased EAAT3 Expression. CONICYT Chile.

2016-2017    Investigador Responsable. FONIS. Evaluación de Polimorfismos como Biomarcadores de Resistencia Farmacológica en pacientes con Epilepsia del Policlínico de Neurología del Hospital Carlos van Buren. Nº SA16I0003. FONDEF Chile.

2016-2017     Co-Investigador. FONDECYT Regular 1160398. Neonatal programming: Sex hormones excess disrupts midbrain dopamine function in the adulthood. CONICYT Chile.

2016-2021     Investigador Adjunto. Instituto Milenio Centro Interdisciplinario en Neurociencias de Valparaíso CINV, Nº P09-022-F, Iniciativa Científica Milenio.

2015-2017     Director Alterno. Núcleo Milenio Neurobiology of Neuropsychiatric Disorders NU-MIND, Nº NC130011, Iniciativa Científica Milenio.

2014-2016     Investigador Responsable. FONDECYT Regular 1141272 Generation and functional characterization of mice with altered expression of EAAT3: A model for obsessive-compulsive disorder. CONICYT Chile.

PUBLICACIONES

  • Ardiles NM, Tapia-Cuevas V, Estay SF, Alcaino A, Velásquez VB, Sotomayor-Zárate R, Chávez AE, Moya PR. Increased forebrain EAAT3 expression confers resilience to chronic stress. J Neurochem. 2025 Jan;169(1):e16216. doi: 10.1111/jnc.16216. Epub 2024 Sep 8. PMID: 39245629.https://pubmed.ncbi.nlm.nih.gov/39245629/
  • Lutz M, Moya PR, Gallorio S, Ríos U, Arancibia M. Effects of Dietary Fiber, Phenolic Compounds, and Fatty Acids on Mental Health: Possible Interactions with Genetic and Epigenetic Aspects. Nutrients. 2024 Aug 6;16(16):2578. doi: 10.3390/nu16162578. PMID: 39203714; PMCID: PMC11356825. https://pubmed.ncbi.nlm.nih.gov/39203714/
  • Cortés BI, Meza RC, Ancatén-González C, Ardiles NM, Aránguiz MI, Tomita H, Kaplan DR, Cornejo F, Nunez-Parra A, Moya PR, Chávez AE, Cancino GI. Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice. Biol Res. 2024 Jun 18;57(1):40. doi: 10.1186/s40659-024-00522-0. PMID: 38890753; PMCID: PMC11186208. https://pubmed.ncbi.nlm.nih.gov/38890753/
  • Crowley JJ, Cappi C, Ochoa-Panaifo ME, Frederick RM, Kook M, Wiese AD… Moya PR, et al. Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol. Am J Med Genet B Neuropsychiatr Genet. 2024 Jun;195(4):e32962. doi: 10.1002/ajmg.b.32962. Epub 2023 Nov 9. PMID: 37946624; PMCID: PMC11076176. https://pubmed.ncbi.nlm.nih.gov/37131804/
  • Illesca-Matus R, Ardiles NM, Munoz F, Moya PR. Implications of Physical Exercise on Episodic Memory and Anxiety: The Role of the Serotonergic System. Int J Mol Sci. 2023 Jul 12;24(14):11372. doi: 10.3390/ijms241411372. PMID: 37511128; PMCID: PMC10379296. https://pubmed.ncbi.nlm.nih.gov/37511128/
  • Ríos U, Morán J, Hermosilla J, González R, Muñoz P, Arancibia M, Herrera L, Jiménez JP, Moya PR. The interaction of the oxytocin receptor gene and child abuse subtypes on social cognition in euthymic patients with bipolar disorder type I. Front Psychiatry. 2023 Apr 17;14:1151397. doi: 10.3389/fpsyt.2023.1151397. PMID: 37139326; PMCID: PMC10150996. https://pubmed.ncbi.nlm.nih.gov/37139326/
  • Pérez-Núñez R, Chamorro A, González MF, Contreras P, Artigas R, Corvalán AH, van Zundert B, Reyes C, Moya PR, Avalos AM, Schneider P, Quest AFG, Leyton L. Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis. J Neuroinflammation. 2023 Jan 6;20(1):5. doi: 10.1186/s12974-022-02677-7. PMID: 36609298; PMCID: PMC9817390. https://pubmed.ncbi.nlm.nih.gov/36609298/
  • Zazueta A, Castillo T, Cavieres Á, González R, Abarca M, Nieto RR, Deneken J, Araneda C, Moya PR, Bustamante ML. Polymorphisms in Schizophrenia-Related Genes Are Potential Predictors of Antipsychotic Treatment Resistance and Refractoriness. Int J Neuropsychopharmacol. 2022 Sep 28;25(9):701-708. doi: 10.1093/ijnp/pyac025. PMID: 35416253; PMCID: PMC9515128. https://pubmed.ncbi.nlm.nih.gov/35416253/
  • Escobar AP, Martínez-Pinto J, Silva-Olivares F, Sotomayor-Zárate R, Moya PR. Altered Grooming Syntax and Amphetamine-Induced Dopamine Release in EAAT3 Overexpressing Mice. Front Cell Neurosci. 2021 Jun 21;15:661478. doi: 10.3389/fncel.2021.661478. PMID: 34234648; PMCID: PMC8255620. https://pubmed.ncbi.nlm.nih.gov/34234648/
  • Spaas J, van Veggel L, Schepers M, Tiane A, van Horssen J, Wilson DM, Moya PR, Piccart E, Hellings N, Eijnde BO, Derave W, Schreiber R, Vanmierlo T. Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders. Cell Mol Life Sci. 2021 May;78(10):4615-4637. doi: 10.1007/s00018-021-03802-0. Epub 2021 Mar 10. PMID: 33751149; PMCID: PMC8195802. https://pubmed.ncbi.nlm.nih.gov/33751149/
  • Ríos U, Moya PR, Urrejola Ó, Hermosilla J, Gonzalez R, Muñoz P, Moran J, Solervicens P, Jiménez JP. El maltrato infantil y su rol en el curso clínico de pacientes con trastorno bipolar [History of child abuse among patients with bipolar disorders]. Rev Med Chil. 2020 Feb;148(2):204-210. Spanish. doi: 10.4067/s0034-98872020000200204. PMID: 32730497. https://pubmed.ncbi.nlm.nih.gov/32730497/
  • Riquelme-Alcázar J, González-Vargas R, Moya PR. Transportadores ABC y resistencia a fármacos en la epilepsia: plausibilidad biológica, farmacogenética y medicina de precisión [ABC transporters and drug resistance in epilepsy: biological plausibility, pharmacogenetics and precision medicine]. Rev Neurol. 2020 Jan 1;70(1):23-32. Spanish. doi: 10.33588/rn.7001.2019188. PMID: 31845753. https://www.neurologia.com/70/1/10.33588/rn.7001.2019188
  • Cavieres A, Campos-Estrada C, Moya Y, Maldonado R, González-Vargas R, Bustamante ML, Moya PR. Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine. Schizophr Res Treatment. 2019 Jun 25;2019:5601249. doi: 10.1155/2019/5601249. PMID: 31341681; PMCID: PMC6614962. https://pmc.ncbi.nlm.nih.gov/articles/PMC6614962/
  • Pérez MÁ, Morales C, Santander O, García F, Gómez I, Peñaloza-Sancho V, Fuentealba P, Dagnino-Subiabre A, Moya PR, Fuenzalida M. Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats. Front Cell Neurosci. 2019 Aug 20;13:372. doi: 10.3389/fncel.2019.00372. PMID: 31481877; PMCID: PMC6710447. https://pubmed.ncbi.nlm.nih.gov/31481877/
  • Escobar AP, Wendland JR, Chávez AE, Moya PR. The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder. Front Pharmacol. 2019 Nov 15;10:1362. doi: 10.3389/fphar.2019.01362. PMID: 31803055; PMCID: PMC6872633. https://pubmed.ncbi.nlm.nih.gov/31803055/
  • Delgado-Acevedo C, Estay SF, Radke AK, Sengupta A, Escobar AP, Henríquez-Belmar F, Reyes CA, Haro-Acuña V, Utreras E, Sotomayor-Zárate R, Cho A, Wendland JR, Kulkarni AB, Holmes A, Murphy DL, Chávez AE, Moya PR. Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. Neuropsychopharmacology. 2019 May;44(6):1163-1173. doi: 10.1038/s41386-018-0302-7. Epub 2018 Dec 26. Erratum in: Neuropsychopharmacology. 2019 May;44(6):1177. doi: 10.1038/s41386-019-0331-x. PMID: 30622300; PMCID: PMC6462043. https://pubmed.ncbi.nlm.nih.gov/30622300/
  • Núñez-Vivanco G, Fierro A, Moya PR, Iturriaga-Vásquez P, Reyes-Parada M. 3D similarities between the binding sites of monoaminergic target proteins. PLoS One. 2018 Jul 20;13(7):e0200637. doi: 10.1371/journal.pone.0200637. PMID: 30028869; PMCID: PMC6054423. https://pubmed.ncbi.nlm.nih.gov/30028869/
  • Bonansco C, Martínez-Pinto J, Silva RA, Velásquez VB, Martorell A, Selva MV, Espinosa P, Moya PR, Cruz G, Andrés ME, Sotomayor-Zárate R. Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats. J Neuroendocrinol. 2018 Jul;30(7):e12574. doi: 10.1111/jne.12574. PMID: 29377365.https://pubmed.ncbi.nlm.nih.gov/29377365/
  • Moya PR, Wendland JR, Fox MA. Dennis Luke Murphy, M.D. (1936-2017). Genes Brain Behav. 2018 Mar;17(3):e12455. doi: 10.1111/gbb.12455. PMID: 29596735. https://pubmed.ncbi.nlm.nih.gov/29596735/
  • González LF, Henríquez-Belmar F, Delgado-Acevedo C, Cisternas-Olmedo M, Arriagada G, Sotomayor-Zárate R, Murphy DL, Moya PR. Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice. Biol Res. 2017 Sep 19;50(1):29. doi: 10.1186/s40659-017-0138-3. PMID: 28927446; PMCID: PMC5605982. https://pubmed.ncbi.nlm.nih.gov/28927446/
  • Ahumada C, Bahamondes C, Cerda CA, Silva RA, Cruz G, Moya PR, Sotomayor-Zárate R, Renard GM. Amphetamine treatment affects the extra-hypothalamic vasopressinergic system in a sex- and nucleus-dependent manner. J Neuroendocrinol. 2017 Apr;29(4). doi: 10.1111/jne.12465. PMID: 28235136. https://pubmed.ncbi.nlm.nih.gov/28235136/
  • Muñoz P, Aschrafi A, Moya PR. Connecting Synaptic Activity with Plasticity-Related Gene Expression: From Molecular Mechanisms to Neurological Disorders. Neural Plast. 2016;2016:7149527. doi: 10.1155/2016/7149527. Epub 2016 Mar 20. PMID: 27088015; PMCID: PMC4818811. https://pubmed.ncbi.nlm.nih.gov/27088015/
  • Espinosa P, Silva RA, Sanguinetti NK, Venegas FC, Riquelme R, González LF, Cruz G, Renard GM, Moya PR, Sotomayor-Zárate R. Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats. Neural Plast. 2016;2016:4569785. doi: 10.1155/2016/4569785. Epub 2016 Jan 10. PMID: 26904299; PMCID: PMC4745917. https://pubmed.ncbi.nlm.nih.gov/26904299/
  • Sotomayor-Zárate R, Jara P, Araos P, Vinet R, Quiroz G, Renard GM, Espinosa P, Hurtado-Guzmán C, Moya PR, Iturriaga-Vásquez P, Gysling K, Reyes-Parada M. Improving amphetamine therapeutic selectivity: N,N-dimethyl-MTA has dopaminergic effects and does not produce aortic contraction. Basic Clin Pharmacol Toxicol. 2014 May;114(5):395-9. doi: 10.1111/bcpt.12168. Epub 2013 Dec 7. PMID: 24314229. https://pubmed.ncbi.nlm.nih.gov/24314229/
  • Moya PR, Wendland JR, Rubenstein LM, Timpano KR, Heiman GA, Tischfield JA, King RA, Andrews AM, Ramamoorthy S, McMahon FJ, Murphy DL. Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette’s disorder. Mov Disord. 2013 Aug;28(9):1263-70. doi: 10.1002/mds.25460. Epub 2013 Apr 29. PMID: 23630162; PMCID: PMC3766488. https://pubmed.ncbi.nlm.nih.gov/23630162/
  • Murphy DL, Moya PR, Fox MA, Rubenstein LM, Wendland JR, Timpano KR. Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. Philos Trans R Soc Lond B Biol Sci. 2013 Feb 25;368(1615):20120435. doi: 10.1098/rstb.2012.0435. PMID: 23440468; PMCID: PMC3638387. https://pubmed.ncbi.nlm.nih.gov/23440468/
  • Moya PR, Dodman NH, Timpano KR, Rubenstein LM, Rana Z, Fried RL, Reichardt LF, Heiman GA, Tischfield JA, King RA, Galdzicka M, Ginns EI, Wendland JR. Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes. Eur J Hum Genet. 2013 Aug;21(8):850-4. doi: 10.1038/ejhg.2012.245. Epub 2013 Jan 16. PMID: 23321619; PMCID: PMC3722668. https://pubmed.ncbi.nlm.nih.gov/23321619/
  • Moya PR, Wendland JR, Salemme J, Fried RL, Murphy DL. miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. Int J Neuropsychopharmacol. 2013 Apr;16(3):621-9. doi: 10.1017/S1461145712000454. Epub 2012 May 8. PMID: 22564678. https://pubmed.ncbi.nlm.nih.gov/22564678/
  • Stewart SE, Mayerfeld C, Arnold PD, Crane JR, O’Dushlaine C, Fagerness JA, Yu D, Scharf JM, Chan E, Kassam F, Moya PR, Wendland JR, Delorme R, Richter MA, Kennedy JL, Veenstra-VanderWeele J, Samuels J, Greenberg BD, McCracken JT, Knowles JA, Fyer AJ, Rauch SL, Riddle MA, Grados MA, Bienvenu OJ, Cullen B, Wang Y, Shugart YY, Piacentini J, Rasmussen S, Nestadt G, Murphy DL, Jenike MA, Cook EH, Pauls DL, Hanna GL, Mathews CA. Meta-analysis of association between obsessive-compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1. Am J Med Genet B Neuropsychiatr Genet. 2013 Jun;162B(4):367-79. doi: 10.1002/ajmg.b.32137. Epub 2013 Apr 18. PMID: 23606572. https://pubmed.ncbi.nlm.nih.gov/23606572/
  • Fox MA, Panessiti MG, Moya PR, Tolliver TJ, Chen K, Shih JC, Murphy DL. Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans. Pharmacogenomics J. 2013 Dec;13(6):551-7. doi: 10.1038/tpj.2012.35. Epub 2012 Sep 11. PMID: 22964922; PMCID: PMC3562558. https://pubmed.ncbi.nlm.nih.gov/22964922/
  • Sotomayor-Zárate R, Quiroz G, Araya KA, Abarca J, Ibáñez MR, Montecinos A, Guajardo C, Núñez G, Fierro A, Moya PR, Iturriaga-Vásquez P, Gómez-Molina C, Gysling K, Reyes-Parada M. 4-Methylthioamphetamine increases dopamine in the rat striatum and has rewarding effects in vivo. Basic Clin Pharmacol Toxicol. 2012 Dec;111(6):371-9. doi: 10.1111/j.1742-7843.2012.00926.x. Epub 2012 Aug 31. PMID: 22788961. https://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2012.00926.x
  • Khaibullina A, Kenyon N, Guptill V, Quezado MM, Wang L, Koziol D, Wesley R, Moya PR, Zhang Z, Saha A, Mukherjee AB, Quezado ZM. In a model of Batten disease, palmitoyl protein thioesterase-1 deficiency is associated with brown adipose tissue and thermoregulation abnormalities. PLoS One. 2012;7(11):e48733. doi: 10.1371/journal.pone.0048733. Epub 2012 Nov 6. PMID: 23139814; PMCID: PMC3490854. https://pubmed.ncbi.nlm.nih.gov/23139814/
  • Liu X, Cannon DM, Akula N, Moya PR, Knudsen GM, Arentzen TE, Steele J, Laje G, Drevets WC, McMahon FJ. A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study. Mol Psychiatry. 2011 Jun;16(6):584-5. doi: 10.1038/mp.2011.1. Epub 2011 Feb 22. PMID: 21339755; PMCID: PMC3100391. https://pubmed.ncbi.nlm.nih.gov/21339755/
  • Murphy DL, Moya PR. Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease. Curr Opin Pharmacol. 2011 Feb;11(1):3-10. doi: 10.1016/j.coph.2011.02.008. Epub 2011 Mar 23. PMID: 21439906; PMCID: PMC3487694. https://pubmed.ncbi.nlm.nih.gov/21439906/
  • Moya PR, Fox MA, Jensen CL, Laporte JL, French HT, Wendland JR, Murphy DL. Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol. 2011 Apr 7;11:3. doi: 10.1186/1471-2210-11-3. PMID: 21473759; PMCID: PMC3080299. https://pubmed.ncbi.nlm.nih.gov/21473759/
  • Moya PR, Murphy DL, McMahon FJ, Wendland JR. Increased gene expression of diacylglycerol kinase η in bipolar disorder. Int J Neuropsychopharmacol. 2010 Sep;13(8):1127-8. doi: 10.1017/S1461145710000593. Epub 2010 Jun 2. PMID: 20519059; PMCID: PMC2928712. https://pubmed.ncbi.nlm.nih.gov/20519059/
  • Omata N, Chiu CT, Moya PR, Leng Y, Wang Z, Hunsberger JG, Leeds P, Chuang DM. Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice. Int J Neuropsychopharmacol. 2011 Jun;14(5):711-7. doi: 10.1017/S1461145710000726. Epub 2010 Jul 7. PMID: 20604988; PMCID: PMC3125712. https://pubmed.ncbi.nlm.nih.gov/20604988/
  • Wendland JR, Moya PR, Timpano KR, Anavitarte AP, Kruse MR, Wheaton MG, Ren-Patterson RF, Murphy DL. A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry. 2009 Apr;66(4):408-16. doi: 10.1001/archgenpsychiatry.2009.6. PMID: 19349310; PMCID: PMC2775716. https://pubmed.ncbi.nlm.nih.gov/19349310/
  • Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Timpano KR, Murphy DL. A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet. 2008 Mar 1;17(5):717-23. doi: 10.1093/hmg/ddm343. Epub 2007 Nov 30. PMID: 18055562. https://pubmed.ncbi.nlm.nih.gov/18055562/
  • Murphy DL, Fox MA, Timpano KR, Moya PR, Ren-Patterson R, Andrews AM, Holmes A, Lesch KP, Wendland JR. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology. 2008 Nov;55(6):932-60. doi: 10.1016/j.neuropharm.2008.08.034. Epub 2008 Sep 11. PMID: 18824000; PMCID: PMC2730952. https://pubmed.ncbi.nlm.nih.gov/18824000/
  • Gobbi M, Funicello M, Gerstbrein K, Holy M, Moya PR, Sotomayor R, Forray MI, Gysling K, Paluzzi S, Bonanno G, Reyes-Parada M, Sitte HH, Mennini T. N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents. J Neurochem. 2008 Jun;105(5):1770-80. doi: 10.1111/j.1471-4159.2008.05272.x. Epub 2008 Feb 4. PMID: 18248615; PMCID: PMC4502523. https://pubmed.ncbi.nlm.nih.gov/18248615/
  • Moya PR, Berg KA, Gutiérrez-Hernandez MA, Sáez-Briones P, Reyes-Parada M, Cassels BK, Clarke WP. Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. J Pharmacol Exp Ther. 2007 Jun;321(3):1054-61. doi: 10.1124/jpet.106.117507. Epub 2007 Mar 2. PMID: 17337633. https://pubmed.ncbi.nlm.nih.gov/17337633/
  • Valdecantos P, Briones R, Moya PR, Germain A, Huidobro-Toro JP. Pharmacological identification of P2X1, P2X4 and P2X7 nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels. Placenta. 2003 Jan;24(1):17-26. doi: 10.1053/plac.2002.0862. PMID: 12495655. https://pubmed.ncbi.nlm.nih.gov/12495655/
  • Acuña-Castillo C, Villalobos C, Moya PR, Sáez P, Cassels BK, Huidobro-Toro JP. Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT(2A) and 5-HT(2C) receptors. Br J Pharmacol. 2002 Jun;136(4):510-9. doi: 10.1038/sj.bjp.0704747. PMID: 12055129; PMCID: PMC1573376. https://pubmed.ncbi.nlm.nih.gov/12055129/